Beilstein J. Org. Chem.2013,9, 2715–2750, doi:10.3762/bjoc.9.308
can be further advanced by kinetic studies and the isolation and characterization of key intermediates.
Keywords: alkyne; azide; Click; copper; CuAAC; DFT study; Huisgen–Meldal–Sharplesscycloaddition; kinetics; reaction mechanism; Introduction
In 1893, Michael discovered a reaction between dimethyl
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Graphical Abstract
Scheme 1:
Exemplary 1,3-dipolar cycloaddition of phenylacetylene with phenyl azide [6].